Description
An inhibitor of microtubule polymerization and an anthelmintic ; reduces microtubule polymerization in a cell-free assay at 10 µM; reduces container attachment, a measure of viability, by G. duodenalis (IB50 = 190 nM); reduces the proliferation of SK-MEL-19 and M14 melanoma cell lines (IC50s = 300 and 320 µM, respectively); and induces apoptosis and PARP cleavage in SK-MEL-19 and M14 cells, but not melanocytes, at 1 µM; decreases oxidative stress-induced cell death in primary mouse cortical neurons in a concentration-dependent manner; decreases tumor volume, weight, hemoglobin levels, and vascularization in an H460 lung cancer mouse xenograft model at 800 µg/animal every other day; eradicates S. vulgaris, S. edentates, and S. equinus worm burden in infected ponies at 8.8 mg/kg